By suppressing gonadotropins, reducing ovarian androgen secretion, and increasing sex hormone-binding globulin levels, oral contraceptives decrease serum testosterone concentrations. Oral contraceptives may be used in women older than 15 years who have no known contraindications to this form of therapy. They are often prescribed to prevent pregnancy in patients who are given 13-cis-retinoic acid.
Acne is one of the most frequently encountered skin diseases in adolescents. Both genders are affected equally, but onset in girls is a little earlier. This may be because girls reach puberty at a younger age than boys. Acne is more noticeable during adolescence because the endocrine glands that influence the sebaceous glands (responsible for secretion of sebum or oil) are on their highest performance. Acne seems to have stemmed from the interaction of hormonal, bacterial, and genetic factors.
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